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JOINT MOBILITY WITH PARTICULAR REFERENCE TO RACIAL VARIATION AND INHERITED CONNECTIVE TISSUE DISORDERS |
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| Authors: | WORDSWORTH, P. OGILVIE, D. SMITH, R. SYKES, B. |
| Affiliation: | 1University of Oxford, Nuffield Departments of Pathology, John Radcliffe Hospital Oxford OX3 9DU, UK 2University of Oxford, Nuffield Departments of Orthopaedic Surgery, John Radcliffe Hospital Oxford OX3 9DU, UK |
| Abstract: | Joint mobility scores were compared in 248 normal English Caucasianmales and females between the ages of 8 and 70 years. The resultswere contrasted with those in a group of normal Asian Indiansand patients suffering from a variety of inherited disordersincluding Type II Ehlers-Danlos syndrome (EDS), Type I osteogenesisimperfecta (OI), Marfan syndrome, generalized osteoarthritis(GOA), achondroplasia and pseudoachondroplasia. The first-degreerelatives of ten subjects with severe or lethal OI were alsoexamined. Asian Indians were significantly more mobile thanEnglish Caucasians. Males and females with EDS were hypermobilebut only the females with OI and the female relatives of thosewith severe or lethal OI showed excess joint laxity. Patientswith pseudoachondroplasia exhibited a grosser type of jointlaxity than other subjects while those with GOA representeda relatively stiff group. No evidence was found to support theview that hypermobility is associated with particular lengthvariants at the Type II collagen structural gene locus (COL2A1). KEY WORDS: Hypermobility, Ehlers-Danlos syndrome, Osteogenesis imperfecta, Osteoarthritis |
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