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Navigational deficits in weaver mutant mice
Authors:Robert Lalonde  M. I. Botez
Affiliation:1. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, OH, United States;2. Cincinnati Children''s Hospital Medical Center, Department of Pediatrics, Division of Child & Adolescent Psychiatry, Cincinnati, OH, United States;3. Department of Psychiatry, University of Illinois at Chicago, United States;4. Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States;5. Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL, United States;1. Institut für Strahlwerkzeuge, University of Stuttgart, Pfaffenwaldring 43, 70569 Stuttgart, Germany;2. Graduate School of Advanced Manufacturing Engineering, University of Stuttgart, Nobelstrasse 12, 70569 Stuttgart, Germany;3. Robert Bosch GmbH, Corporate Sector Research and Advance Engineering, Postbox 30 02 40, 70442 Stuttgart, Germany;1. Centre for Mental Health, Swinburne University of Technology, Melbourne, Australia;2. Monash Alfred Psychiatry Research Centre, Melbourne, Australia;3. Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University Central Clinical School, Melbourne, VIC, Australia;1. Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California;2. Department of Psychiatry, University of California San Diego, La Jolla, California;3. VA San Diego Healthcare System, San Diego, California;4. Laureate Institute for Brain Research, Tulsa, Oklahoma;5. Social, Genetic and Developmental Psychiatry Centre, King’s College, London, United Kingdom;6. Health Services & Outcomes Research, Children’s Mercy Hospital, Kansas City, Missouri;1. Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Center for Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany;2. Department of Neurology, University of Lübeck, Lübeck, Schleswig-Holstein, Germany;3. Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Schleswig-Holstein, Germany;4. Department of Psychology, Centre for Innovation in Mental Health, University of Southampton, UK
Abstract:
Weaver mutant mice have selective degeneration of cerebellar granule cells. In comparison to normal mice, the weaver mutants made more errors and took a longer time to reach a platform in a water-maze. Results are discussed in terms of a role for the cerebellum in spatial orientation.
Keywords:Weaver mutant mouse   Cerebellum   Spatial orientation
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