老年衰弱新兴标志物的研究进展及展望

衰弱已被视为一个重大的公共卫生问题，相对于大规模筛查老年衰弱的量表类工具而言，生物标志物可以更早、更客观地识别衰弱高危人群。本文对与衰弱相关的炎症、内分泌、氧化应激标志物等传统生物标志物的新进展以及存在的局限性进行综述，并对蛋白质生物标志物、表观遗传标记、神经元标志物、细胞外水分率比值等新兴标志物的潜在性进行探讨，提出标志物与功能参数结合、建立衰弱核心标志物小组、针对衰弱的过程状态选择不同的标志物等评估衰弱的新方法，应探索有价值的衰弱生物标志物补充到已有的研究中，有利于阐明衰弱的发病机制，对衰弱的预防、诊断及预后具有重要作用。

Emerging Markers of Frailty in Older People: Recent Strides and Prospect

Frailty has been considered as a major public health issue. Compared with scale tools for massive screening for frailty in older people，biomarkers may identify those at high risk for frailty earlier and more objectively. We reviewed the new advances and limitations in traditional biomarkers of frailty，such as inflammation，endocrine and oxidative stress markers，discussed the potentials of new biomarkers such as protein biomarkers，epigenetic markers，neuronal markers and extracellular water fraction，and proposed new methods for frailty evaluation，including combination use of frailty biomarkers and physical function parameters，use of a group of core frailty biomarkers，and use of appropriate frailty biomarkers according to individual frailty level. Exploring valuable frailty biomarkers as a supplement for available studies，is conducive to clarifying the pathogenesis of frailty，and will effectively support the prevention，diagnosis and prognosis improvement of frailty.