首页 | 本学科首页   官方微博 | 高级检索  
     


Production of erythroid cells from human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPS)
Affiliation:1. Division of Geriatric Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;2. Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA;3. Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA;4. Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA;5. Lowe Family Genomics Core, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;6. Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;1. Division of Hematology, Department of Medicine, University of Washington, Seattle, WA;2. Altius Institute for Biomedical Sciences, Seattle, WA;1. Department of Pathology and Laboratory Medicine, Children''s Hospital of Philadelphia, Philadelphia, PA, USA;2. Center for Cellular and Molecular Therapeutics, Children''s Hospital of Philadelphia, Philadelphia, PA, USA;3. Division of Pulmonary, Allergy & Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA;4. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA;5. Division of Hematology, Children''s Hospital of Philadelphia, PA, USA
Abstract:Erythroid progenitors can be generated ex vivo from human embryonic stem cells (hESC) or human induced pluripotent stem cells (hiPS). Development of laboratory scale culture conditions capable of generating mature functional erythrocytes from human embryonic stem cells or human induced pluripotent stem cells would open the possibility for manufacture of therapeutic quantities of red cells and thereby new clinical transfusion products. Current attempts to produce erythrocytes from human embryonic stem cells reveal the need for greater understanding of the process whereby primitive erythropoiesis switches to definitive fetal and adult erythropoiesis and the factors driving erythrocyte maturation. Studies with human embryonic stem cells have already yielded encouraging results but functional mature biconcave erythrocytes have yet to be generated from these cells.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号