Effect of Ginseng Mixture on Osteoporosis in Ovariectomized Rats |
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| Authors: | Hyung-Ryong Kim Yan Cui Su-Jung Hong Sook-Jeong Shin Do-Sung Kim Na-Mi Kim |
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| Affiliation: | 1. Department of Dental Pharmacology, Dental School, Wonkwang University, Iksan, Chonbuk, Republic of Korea;2. Department of Pharmacology, Medical School, Chonbuk National University, Chonbuk, Republic of Korea;3. and Clinical Trial Center for Functional Foods, Chonbuk National Hospital, Jeonju, Chonbuk, Republic of Korea;4. KT&5. G Central Research Institute, Daejeon, Republic of Korea |
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| Abstract: | ![]()
In this study, the authors have characterized the effect of HER-S (red ginseng, Angelicae gigantis Radix, Phyllostachys folium, and soybean extracts) on osteoporosis-associated phenomena in ovariectomized (OVX) rats by measuring body weights and bone histomorphometries in control, sham, OVX, OVX(β-estradiol–treated), and OVX(HER-S–treated) rats. Light microscopic analyses showed a porous or eroded appearance on the femoral trabecular bone surface in OVX rats, whereas the femoral trabecular bone surfaces of the other groups (control, sham, OVX(17β-estradiol–treated), and OVX(HER-S–treated) rats) were composed of fine particles. The femoral trabecular bone area and number were decreased in OVX rats, but these reductions were significantly prevented by the administration of HER-S for 7 weeks, similar to estrogen. In the blood biochemistry results, serum phosphorus, calcium, T3, and T4 remained unchanged, but blood estrogen levels were significantly increased in HER-S–treated rats, which suggests that estrogen is related to the mechanism of the HER-S–induced antiosteoporosis function in OVX rats. |
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| Keywords: | Anti-Osteoporosis HER-S Red Ginseng Osteoporosis Ovariectomy |
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