Treatment with DNAse I fosters binding to nec PBMC of CRP |
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| Authors: | Christina Janko Christine Schorn Daniela Weidner Kerstin Sarter Ricardo Chaurio Ahmed Sheriff |
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| Affiliation: | 1. Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germanychristina.janko@uk-erlangen.de;3. Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany;4. Department of Medicine, Division of Nephrology and Intensive Care Medicine, Charité Berlin Campus Virchow-Klinikum, Berlin, Germany |
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| Abstract: | CRP is an important inflammatory marker, however, CRP levels are relatively low in patients with SLE. In addition patients with SLE often display low activities and serum levels for DNase I and complement, respectively. Here we show that DNase I treatment of nec PBMC increased their binding of CRP. Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells. |
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| Keywords: | CRP DNase I nec SLE |
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