液态纳米骨修复材料★

摘要：检索Pubmed数据库和中国期刊全文数据库文献，总结各种类型和性质的纳米骨修复材料的研究现状及最新进展。纳米仿生骨常用多孔陶瓷为支架,在体外培养细胞,扩增形成骨组织再植入体内。常见的原料有纳米磷酸钙／胶原材料、多孔仿珊瑚人工骨、纳米羟晶磷灰石/胶原仿生骨、纳米羟基磷灰石／胶原材料、脱钙骨基质/胶原材料等。羟基磷灰石、氧化铝陶瓷、磷酸三钙是用于制备纳米陶瓷的材料。纳米陶瓷是最常用的组织工程材料。纳米复合陶瓷材料有良好的生物相容性。以钙为主要成分，采用最新的生物纳米技术合成的可吸收注射型纳米骨浆具有自塑能力，植入后重塑良好。这些结果证实，纳米骨修复材料的主要用途是作为细胞外支架和骨折的固定材料，已在组织工程和生物材料研究中显示出优异的生物学性能及广阔的应用前景。

Liquid nano-materials for bone repair

Abstract: A search of Pubmed database and China Journal Full-text Database was undertaken to summarize the research status and latest advances in varieties of nano-materials with different capabilities, which are applied for bone repair. By adopting porous ceramic as scaffolds, the bionic nano-bone forms bone tissues by in vitro culture and amplification of the cells, then is applied for the transplantation. The common materials include nano-calcium phosphate/collagen material, porous coral artificial bone, nano-hydroxyapatite ceramic/collagen biotic bone, nano-hydroxyapatite ceramic/collagen material, and decalcified bone matrix/collagen material, etc. Nano-ceramic materials are mainly prepared with hydroxyapatite ceramic, aluminium oxide ceramic and tricalcium phosphate. Nano-materials are the most dominant tissue engineering materials. Nano-ceramic compound materials have a good biocompatibility. Taking calcium as the main component, the new kind of absorbable and injectable nano-bone, which is synthesized by bio-nano technique, has shown self-construction ability and obtained good reconstruction after implantation. These all prove that, nano-bone materials for bone repair are chiefly used for extracellular scaffolds and fixation materials of the fracture, they have revealed excellent biological capabilities and broad prospects for application in tissue engineering and biological material fields.