慢性阻塞性肺疾病急性加重期患者血清降钙素原与前白蛋白检测的临床意义

目的: 探讨血清降钙素原(PCT)及血清前白蛋白(PA)检测在慢性阻塞性肺疾病急性加重期(AECOPD)患者疗效观察中的应用价值.方法: 检测72例AECOPD患者治疗前后血清PCT、PA、白细胞(WBC)、血气分析及痰培养,比较治疗前后的变化.结果: 痰培养阳性与阴性患者治疗前血清PCT和PA差异均无统计学意义(P>0.05),2组治疗前后WBC计数变化差异均无统计学意义(P>0.05),但血清PCT和PA治疗前后变化差异均有统计学意义(P<0.01).结论: AECOPD患者血清PCT及PA变化较大,是较好的诊断指标,PCT及PA两者联合诊断意义更大,对AECOPD细菌感染的诊断及病情监测具有重要参考价值.

Clinical application of serum procalitonin and prealbumin levels in patients with acute exacerbations of chronic obstructive pulmonary disease

Objective： To investigate the clinical application value of serum procalcitionin（ PCT） and prealbumin（ PA） level in patients with acute exacerbations of chronic obstructive pulmonary disease（ AECOPD）. Methods： The changes of serum PCT,PA and white blood cell（ WBC） levels,blood gas analysis and sputum culture of 72 patients with AECOPD before and after treatment were detected and compared. Results： There was no statistical differences of serum PCT and PA levels before treatment between sputum culture positive and negative groups（ P〉0. 05）,white blood cell count didn＇t change before and after treatment（ P 〉0. 05）,however,there had statistical differences of serum PCT and PA levels before and after treatment（ P〈0.01）. Conclusions： The changes of serum PCT and PA levels in AECOPD patients were more obvious,which were good diagnostic indicators. Combined with PCT and PA had more important reference value for AECOPD bacterial infection diagnosis and disease monitoring.