| 选择性N-甲基-D-天门冬氨酸受体NR2B亚型阻滞剂的研究进展 |
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| 引用本文： | 董国兴,杨日芳,李锦,恽榴红.选择性N-甲基-D-天门冬氨酸受体NR2B亚型阻滞剂的研究进展[J].中国新药杂志,2006,15(23):2013-2018. |
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| 作者姓名： | 董国兴 杨日芳 李锦 恽榴红 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 选择性N-甲基-D-天门冬氨酸受体NR2B亚型阻滞剂近年来受到了越来越多的关注。目前，已报道的NR2B亚型阻滞剂的结构类型绝大多数仍为艾芬地尔发展而来的哌啶衍生物，另外还有酰胺、脒、氨基喹啉等结构类型；NR2B亚型阻滞剂在神经元保护、镇痛、抗药物依赖、抗帕金森病等方面表现了潜力。现根据不同结构类型综述NR2B亚型阻滞剂的结构及药理活性，并探讨其毒副作用较低的可能原因和临床应用潜力。
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| 关 键 词： | NMDA受体 NR2B亚型阻滞剂 艾芬地尔 药物依赖 |
| 文章编号： | 1003-3734（2006）23-2013-06 |
| 收稿时间： | 2006-07-10 |
| 修稿时间： | 2006年7月10日 |
Progresses on NR2B subtype selective NMDA receptor antagonists |
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| DONG Guo-xing,YANG Ri-fang,LI Jin,YUN Liu-hong.Progresses on NR2B subtype selective NMDA receptor antagonists[J].Chinese Journal of New Drugs,2006,15(23):2013-2018. |
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| Authors: | DONG Guo-xing YANG Ri-fang LI Jin YUN Liu-hong |
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| Institution: | Institute of Pharmacology and Toxicology, The Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | NR2B subtype selective NMDA receptor antagonists have received considerable attentions in recent years. Currently, most of the NR2B antagonists known are structurally related to ifenprodil, and some belongs to the types of amides, amidines and aminoquinolines. The NR2B antagonists have shown the potential in neuronal protection and prophylaxis of hyperalgesia, drug-dependence and Parkinsong diseases in rodent models. This review presents the correlationship of structure types of the NR2B antagonists with their pharmacological properties together with the rational and clinical therapy of the NR2B antagonists with lower side effects. |
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| Keywords: | NMDA receptor NR2B antagonists ifenprodil drug-dependence |
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