层黏连蛋白及其受体在胃癌中的表达及其与侵袭和转移的关系

目的 :探讨层黏连蛋白 (LN)和LN受体 (LN R)的表达与胃癌侵袭和转移的关系。方法 :应用免疫组织化学S P法检测 68例胃癌组织中LN和LN R的表达。结果 :LN在有淋巴结转移组中阳性表达率明显低于无转移组 ,P <0 0 1;LN在其他各组中的表达差异无统计学意义 ,P >0 0 5 ;LN R的阳性表达率有随肿瘤分化水平的降低、浸润深度的增加而增高 ,P <0 0 1;淋巴结转移组中的LN R表达明显高于无淋巴结转移组 ,P <0 0 0 1。结论 :LN的低表达与肿瘤的转移有关 ,LN R的高表达与肿瘤分化、侵袭和转移的关系十分密切。LN和LN R可作为胃癌进展的重要生物学指标之一。

Relationship between laminin and laminin receptor expressions and invasion and metastasis of gastric carcinoma

OBJECTIVE:To investigate the relationship between laminin (LN) and LN receptor (LN-R) expressions and gastric carcinoma invasion and metastasis.METHODS:The LN and LN-R expressions in 68 cases of human gastric carcinoma were examined by useing the immunohistochemical S-P methods and the expressions were analyzed with their relation to invasion and metastasis.RESULTS:LN positive expression in lymph node metastasis group was lower than that in negative lymph node metastasis group,P<0.01, but the relation to other groups was not significant,P> 0.05. The positive rate of LN-R gradually raised with the decline of tumor cell differentiated level and the increase of invasive depth P<0.01. LN-R expression was significantly higher in positive lymph node metastasis group than that in negative lymph node metastasis group,P<0.001. CONCLUSIONS: These results suggest that lower expression of LN is related to metastasis of gastric carcinoma, and higher expression of LN-R is correlated with differention level,depth of invasion and metastasis. LN and LN-R expressions are important biofactors for predicting the prognosis of gastric carcinomas.