Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation |
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| Authors: | Jen-Tsun?Lin,Ming-Yang?Lee,Lian-Tsai?Hsiao,Mu-Hua?Yang,Ta-Chon?Chao,Po-Min?Chen,Tzeon-Jye?Chiou mailto:tjchiou@vghtpe.gov.tw" title=" tjchiou@vghtpe.gov.tw" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, #201, Sec.2, Shi-Pai Road, Shi-Pai, 112 Taipei, Taiwan;(2) School of Medicine, National Yang-Ming University, Taipei, Taiwan |
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| Abstract: | ![]()
We describe a case of pulmonary nocardiosis in a female patient with graft-versus-host disease (GVHD) underwent therapy with imatinib mesylate for a relapse of chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT). The patient developed chronic GVHD 8 months after the use of imatinib and was on corticosteroid therapy. Three months after the development of chronic GVHD, she acquired pulmonary nocardiosis and a computed tomography (CT) scan of the chest showed multiple nodular lesions with cavitations over both lungs. She was successfully treated with single-agent trimethoprim-sulfamethoxazole (TMP/SMX) and the infection did not recur. Our case indicated that pulmonary nocardiosis could occur in patients with GVHD undergoing imatinib and corticosteroid therapy and might be treated by single-agent TMP/SMX.Conflicts of interest: none for all authors, and there were no extra-institutional grants |
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| Keywords: | Nocardiosis Bone marrow transplantation Imatinib mesylate |
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