| 高效液相色谱法测定麦迪霉素片中麦迪霉素A_1的含量 |
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| 引用本文： | 陈海燕,卓芝,曾杰. 高效液相色谱法测定麦迪霉素片中麦迪霉素A_1的含量[J]. 中国药房, 2003, 14(2): 111-112 |
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| 作者姓名： | 陈海燕 卓芝 曾杰 |
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| 作者单位： | 重庆市药品检验所,重庆市 400015 |
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| 摘 要： | 目的 :建立测定麦迪霉素片中麦迪霉素A1 含量的方法。方法 :采用高效液相色谱法 ,以C18 为色谱柱 ,0 1mol/L甲酸铵溶液 -乙腈 (80∶55)为流动相 ,检测波长为232nm。结果 :麦迪霉素A1 浓度在0 5～8mg/ml范围内线性关系良好 ,回归方程为S=5989C—24 65 ,r=0 9995 ;重现性RSD=1 4 % (n=5) ;平均回收率为99 35 % ,RSD=1 2 % (n=6)。结论 :该法简便易行 ,可用于麦迪霉素片的质量控制。
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| 关 键 词： | 麦迪霉素片 麦白霉素片 麦迪霉素A1 高效液相色谱法 |
| 文章编号： | 1001-0408(2003)02-0111-02 |
| 修稿时间： | 2002-03-20 |
Determination of Midecamycin A1 in Midecamycin Tablets by HPLC |
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| CHEN Haiyan,ZHUO Zhi,ZENG Jie. Determination of Midecamycin A1 in Midecamycin Tablets by HPLC[J]. China Pharmacy, 2003, 14(2): 111-112 |
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| Authors: | CHEN Haiyan ZHUO Zhi ZENG Jie |
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| Abstract: | OBJECTIVE:To establish a method of determination of midecamycin A1 in midecamycin tablets METHODS:This method used C18 column as stationary phase,0 1mol/L ammonium formate solution-acetonitrile(80∶55) as mobile phase and 232nm as detection wavelength RESULTS:There was a good linear correlation in the range of 0 5～8mg/ml,r=0 9 995,S=5 989C-24 65,RSD=1 4%(n=5) The mean recovery was 99 35% and RSD=1 2%(n=6) CONCLUSION:The method is simple and easy to do and may be adopted for quality control of this drug |
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| Keywords: | midecamycin tablets meleumycin tablets midecamycin A1 HPLC |
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