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| 硫酸化香菇分级多糖抗肿瘤活性的研究 | |
| 引用本文： | 麻兵继,冯雅岚,申进文,戚元成,高玉千,邱立友.硫酸化香菇分级多糖抗肿瘤活性的研究[J].中国药师,2010,13(4):451-453. |
| 作者姓名： | 麻兵继 冯雅岚 申进文 戚元成 高玉千 邱立友 |
| 作者单位： | 1. 河南农业大学农学院,郑州,450002 2. 河南省信阳市农业科学研究所 3. 河南农业大学生命科学学院 |
| 基金项目： | 河南省重大科技攻关项目 |
| 摘 要： | 目的：研究硫酸化香菇分级多糖抗肿瘤活性。方法：提取香菇子实体多糖，用浓硫酸法进行结构修饰，经不同分子量超滤膜超滤进行分级，再对分级组分进行抗肝癌细胞HepG2活性检测。结果：得到6个香菇硫酸化分级多糖，其中两个组分有显著抗肿瘤活性。结论：在一定浓度范围内硫酸化分级多糖抗肝癌细胞的活性呈量效关系，且低分子量组分活性强于高分子量组分。 |
| 关 键 词： | 食用菌 药用菌 香菇 子实体 超滤 |
Study on Anti-tumor Activity of Sulfated Dractional Lentinan in Vitro |
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| Ma Bingji,Feng Yalan,Shen Jinwen,Qi Yuancheng,Gao Yuqian,Qiu Liyou.Study on Anti-tumor Activity of Sulfated Dractional Lentinan in Vitro[J].China Pharmacist,2010,13(4):451-453. | |
| Authors: | Ma Bingji Feng Yalan Shen Jinwen Qi Yuancheng Gao Yuqian Qiu Liyou |
| Institution: | Ma Bingji~1,Feng Yalan~2,Shen Jinwen~3,Qi Yuancheng~3,Gao Yuqian~3,Qiu Liyou~3(1.College of Agriculture,Henan Agricultural University,Zhengzhou 450002,China,2.Xinyang Institute of Agricultural Science,3.College of Life Science,Henan Agricultural University) |
| Abstract: | Objective:To study the anti-tumor activity of sulfated fractional lentinan.Method:The lentinan were modified by sulfation and treated by using molecular weight cutoff ultrafiltration membrane.Then the fractions were tested for anti-Hep G2 activity in vitro,respectively.Result:Six fractional lentinan were obtained and two of which have significant anti-tumor activity.Conclusion:The sulfated fractional lentinan have the activity of anti-tumor with dose-effect relationship.The low molecular weight of sulfated ... |
| Keywords: | Edible fungi Medicinal fungi Lentinula edodes Fruiting body Ultrafiltration |
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