| 下丘脑对血糖的调节 |
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| 引用本文： | 周闻白（综述）,胡仁明（审校）. 下丘脑对血糖的调节[J]. 国外医学:内科学分册, 2008, 35(6) |
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| 作者姓名： | 周闻白（综述） 胡仁明（审校） |
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| 作者单位： | 复旦大学糖尿病内分泌研究所,复旦大学附属华山医院内分泌科,上海,200040;复旦大学糖尿病内分泌研究所,复旦大学附属华山医院内分泌科,上海,200040 |
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| 摘 要： | 下丘脑腹内侧核(VMH)中存在的血糖感受神经元参与全身血糖稳定状态的调节。其中分为两种不同功能的血糖感受神经元:葡萄糖兴奋神经元——当细胞外周环境中葡萄糖浓度升高时能降低其代谢率;葡萄糖抑制神经元——当外周葡萄糖浓度升高时能提高其代谢率。除VMH外,脑中还有更高级的血糖调节中枢,能和VMH部位通过促肾上腺皮质激素释放因子(CRF)、尿皮质醇及促肾上腺皮质激素释放因子受体(CRFRs)相互作用。1型糖尿病患者对低血糖的负调节反应(CRRs)存在缺陷,导致在胰岛素治疗的过程中发生低血糖事件。研究VMH部位对血糖调节的机制能为其治疗提供新的线索。
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| 关 键 词： | 下丘脑腹内侧核 葡萄糖抑制神经元 葡萄糖兴奋神经元 负调节反应 促肾上腺皮质激素释放因子受体 |
Role of hypothalamus in regulation of glucose homeostasis |
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| ZHOU Wen-bai,HU Ren-ming. Role of hypothalamus in regulation of glucose homeostasis[J]. Foreign Medical Sciences(Section of Internal Medicine), 2008, 35(6) |
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| Authors: | ZHOU Wen-bai HU Ren-ming |
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| Affiliation: | ZHOU Wen-bai,HU Ren-ming.Institute of Endocrinology and Diabetology at Fudan University,Department of Endocrinology,Huashan Hospital,Fudan University,Shanghai 200040,China |
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| Abstract: | Glucose-sensing neurons in the ventromedial hypothalamus(VMH) are involved in the regulation of glucose homeostasis.There are two different Glucose-sensing neurons: VMH glucose-inhibited(GI) neurons decrease their metabolic rates when extracellular glucose concentration increases,while glucose-excited(GE) neurons increase their metabolic rates.There are higher brain centers that communicate with VMH via corticotropin-releasing factor receptors(CRFRs),which are the ligands of CRF and urocortins.Studies on the mechanism of the glucose regulation in VMH will offer a future therapeutic potential for individuals with type 1 diabetes who have defective counterregulatory responses(CRRs) to hypoglycemia. |
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| Keywords: | Ventromedial hypothalamus Glucose-inhibited neurons Glucose-excited neurons Counterregulatory responses Corticotropin-releasing factor receptors |
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