Colchicine poisoning |
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| Affiliation: | 2. Department of Analytical, Environmental and Forensic Sciences, Medical Research Council-Public Health England Centre for Environment and Health, King''s College London, London, United Kingdom;3. National Institute for Health Research Unit, Health Impact of Environmental Hazards, King''s College London, in partnership with Public Health England and Imperial College London, London, United Kingdom;4. Department of Biochemistry, Faculty of Science, Charles University, Prague 2, Czech Republic;5. Clinical Centre Serbia, Belgrade, Serbia;11. Laboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium;1. Department of Pathology, VU University Medical Center, Postbox 7057, 1007, MB, Amsterdam, The Netherlands;2. Department of Cardiology, VU University Medical Center, Postbox 7057, 1007, MB, Amsterdam, The Netherlands;3. Department of Cardiac Surgery, VU University Medical Center, Postbox 7057, 1007, MB, Amsterdam, The Netherlands;4. Institute for Cardiovascular Research of the Vrije Universiteit (ICaR-VU), VU University Medical Center, De Postbox 7057, 1007, MB, Amsterdam, The Netherlands;5. Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Postbox 9892, 1006, AN, Amsterdam, The Netherlands;6. Department of Hematology, Academic Medical Center, Postbox 22660, 1100, DD, Amsterdam, The Netherlands;7. Department of Virology, University Medical Center Utrecht, Postbox 85500, 3508, GA, Utrecht, The Netherlands;8. Department of Cardiology, Maastricht University Medical Center, Postbox 5800, 6202, AZ, Maastricht, The Netherlands |
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| Abstract: | ![]()
Colchicine poisoning is an unusual but serious form of drug intoxication. Although relatively uncommon, colchicine poisoning may produce life-threatening systemic effects that must be recognized and treated by the emergency physician. This alkaloid found in Cokhicum autumnale is used primarily in the treatment of gout. In toxic doses it produces nausea and vomiting, and bone marrow suppression often leading to sepsis, hypocalcemia, adult respiratory distress syndrome, and direct cardiotoxic effects. Treatment requires early recognition and supportive care including fluid and electrolyte replacement and occasionally blood component replacement therapy. Recent experiments using colchicine-specific antibodies have demonstrated beneficial effects on colchicine intoxication. |
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