The effect of alcohol consumption on nutritional status during murine AIDS |
| |
| Affiliation: | 1. Department of Family and Community Medicine, University of Arizona, Tucson, AZ 85724 USA;2. Nutritional Sciences Program, University of Arizona, Tucson, AZ 85724 USA;3. Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85724 USA;1. Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism, Medical University Innsbruck, Austria;2. Department of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology & Pneumology, Medical University Innsbruck, Austria;3. Department of Dermatology, University Hospital Zurich, Switzerland;4. Institute of Pathology, Medical University Innsbruck, Austria;5. Department of Internal Medicine II, Gastroenterology & Hepatology, Medical University Innsbruck, Austria;1. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province; School of Pharmacy, Anhui Medical University, Hefei 230032, China;2. Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China;3. Medical Device Production Supervision Office, Anhui Provincial Drug Administration, Hefei 230051, China;4. Department of Ophthalmology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;1. APC Microbiome Institute, University College Cork, Cork, Ireland;2. Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA;3. Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland;4. Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland;5. Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland;1. College of Pharmacy, Chosun Univerisity, Gwangju, Korea;2. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea;3. College of Pharmacy, Yeungnam University, Gyeongsan, Korea;4. MRC-GHF, College of Korean Medicine, Daegu Haany University, Kyungsan, Kyungsangbuk-do, Korea;1. Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;2. Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China |
| |
| Abstract: | ![]()
As alcohol (ETOH) abusers and AIDS patients have nutritional disorders, the influence of chronic ETOH consumption (5% v/v for 10 weeks) on levels of immunomodulatory nutrients (vitamins A and E, Zn, and Cu) in the serum, liver, small intestine, spleen, and thymus was determined during murine AIDS. The hepatic levels of vitamins A and E and Zn in both normal and LP-BM5 retrovirus-infected female C56BL/6 mice fed ETOH were significantly reduced compared to controls, whereas the level of Cu in the liver was not affected. Intestinal levels of vitamin A and Cu were not affected by ETOH, whereas vitamin E and Zn were significantly reduced in both normal mice and those with AIDS fed ETOH. The splenic levels of vitamin A and Zn in the normal mice were significantly reduced by ETOH compared to controls, but vitamin E and Cu were not. All splenic levels of nutrients measured were reduced in ETOH-fed mice with AIDS. The levels of vitamins A and E, Zn, and Cu in the thymus in murine AIDS were also significantly affected by ETOH consumption. The serum levels of vitamins A and E in both normal mice and murine AIDS were significantly decreased by dietary ETOH. These data produced evidence that chronic ETOH can directly aggravate undernutrition initiated by retrovirus infection. Such ETOH-induced malnutrition in AIDS may be a cofactor, accelerating development of AIDS via immunosuppression secondary to nutritional deficiencies. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
