鼠脑缺血后软脑膜微循环及脑血流自动调节功能的实验研究

本文利用闭合式颅骨开窗的方法制成脑微循环小室,以显微镜摄像系统连续观察双侧颈总动脉阻塞前后软脑膜微循环的变化,发现双侧颈总动脉阻塞后,软脑膜动脉管径和平均动脉压分别增加了40％和58％;静脉内血球流速减少至原值的70％;软脑膜动脉对动脉血二氧化碳浓度升高及低血压所引起的扩张反应受到明显抑制。实验结果提示:双侧颈总动脉阻塞后,虽然脑动脉明显扩张、血压上升。仍不足以代偿由于脑局部灌注压的下降所造成的脑血流量减少。提示双侧颈总动脉阻塞时,脑血流的自动调节功能受到严重损害。

Characterization of pial microcirculation and the function of the cerebral vascular autoregulation following bilateral carotid artery occlusion.

The present study was designed to investigate the acute change of pial microcirculation by closed cranial window technique.Continuously investigated by micro-photo device after occluding bilateral cartoid arteries of rats,the changes of pial ar-terioles velocity and mean arterial blood pressure increased by 40% and 58% respectively,the blood cells in venule decreased to 70%.The effects of high concentration of carbon dioxide (CO2) and hemorrhagic hypotension on pial mi-crocircuatin during bilateal carotid artery occlusion also be observed in different groups.The results showed that folloing the bileteral carotid artery occlusion,the pial arterioles rapidly and significantly dilated and the dilated response of pial arterioles to high concentration of CO2 and hypotension were reduced remarkebly.It was revealed that the cerebral autoregulation was disturbed following bilateral carotid artery occlusion.