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| 胶质细胞源性神经营养因子对运动神经元发育及运动神经元性疾病的作用 | |
| 引用本文： | 蔡炜嵩,赵红宇,袁正伟. 胶质细胞源性神经营养因子对运动神经元发育及运动神经元性疾病的作用[J]. 中国修复重建外科杂志, 2005, 19(6): 490-493 |
| 作者姓名： | 蔡炜嵩 赵红宇 袁正伟 |
| 作者单位： | 1. 中国医科大学第二临床学院(盛京医院)小儿外科,卫生部小儿先天畸形重点实验室,沈阳,110004 2. 中国医科大学第二临床学院(盛京医院)神经外科,卫生部小儿先天畸形重点实验室,沈阳,110004 |
| 基金项目： | 国家自然科学基金资助项目(30371476)，辽宁省科技攻关计划资助项目(2003225007-2)~~ |
| 摘 要： | 目的 追溯近年国内外有关胶质细胞源性神经营养因子(glial cell line-derived neurotropic factor，GDNF)与运动神经元发育及疾病研究的进展。方法 广泛查阅近期有关GDNF与运动神经元关系的文献，综述GDNF的分子结构、作用方式及治疗时给药方式。结果 GDNF对运动神经元发育及运动神经元疾病有广泛的作用，对脊髓运动神经元的发育起一定调控作用，可以挽救出现损伤的运动神经元。结论 GDNF在运动神经元疾病的治疗上，具有潜在的临床价值和不可估量的前途。 |
| 关 键 词： | 胶质细胞源性神经营养因子 运动神经元性疾病 GDNF 分子结构 |
| 修稿时间： | 2003-12-23 |
ROLES OF GLIAL CELL LINE-DERIVED NEUROTROPIC FACTOR IN MOTONEURON DEVELOPMENT AND MOTONEURON DISEASE |
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| CAI Weisong,ZHAO Hongyu,Yuan Zhengwei. ROLES OF GLIAL CELL LINE-DERIVED NEUROTROPIC FACTOR IN MOTONEURON DEVELOPMENT AND MOTONEURON DISEASE[J]. Chinese journal of reparative and reconstructive surgery, 2005, 19(6): 490-493 | |
| Authors: | CAI Weisong ZHAO Hongyu Yuan Zhengwei |
| Affiliation: | Shengjing Hospital |
| Abstract: | Objective To review research progress of the relation between glial cell line-derived neurotropic factor (GDNF) and motoneuron development and motoneuron disease. Methods The recent articles on GDNF and motonerons were extensively reviewed. The molecular structure, the mode of action and the route of administration of GDNF were investigated. Results GDNF plays extensive roles in the development and disease of motoneuron. GDNF might regulate the development of the motonerons of the spinal cord to some extent and also save the injured motoneurons. Conclusion GDNF has a potential clinical value and inestimable future in the treatment of motoneuron diseases. |
| Keywords: | Glial cell line-derived neurotropic factor Motoneuron Development Disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |