B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant |
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| Authors: | Jane Baer Felix Santiago Hongmei Yang Hulin Wu Jeanne Holden-Wiltse John Treanor David J. Topham |
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| Affiliation: | 1. David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology and Immunology, United States;2. Division of Infectious Diseases, Department of Medicine, United States;3. New York Influenza Center of Excellence, United States;4. University of Rochester Center for Biodefense Immune Modeling, Department of Biostatistics and Computational Biology, United States |
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| Abstract: | B cell responses after immunization with a drifted H5 influenza/A/Vietnam/1203/04 vaccine were characterized in the peripheral blood of human subjects primed with experimental recombinant H5 influenza A/Hong Kong/156/97 vaccine. Antibody secreting cells were assayed by ELISPOT against a panel of recombinant hemagglutinin and control proteins. Increased frequencies of H5 HA-specific antibody secreting and memory B cells could be observed within 7 days of re-vaccination. Furthermore, these responses were cross-reactive to both H5 HA variants, but not H3 or avian H6 HA strains. These observations suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains. |
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| Keywords: | Influenza B cell Hemagglutinin |
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