An HIV-based lentiviral vector as HIV vaccine candidate: Immunogenic characterization |
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Authors: | Franck Lemiale Benyam AsefaDelia Ye Christopher ChenNikolay Korokhov Laurent Humeau |
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Institution: | VIRxSYS Corporation, 200 Perry Parkway, Gaithersburg, MD 20877, United States |
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Abstract: | Recently developed viral-vectored HIV vaccine candidates, despite achieving high levels transgene expression and inducing high magnitude immune responses to HIV, have faced limitations related to anti-vector immunity. In contrast, lentiviral vectors (LV) have been shown to be less sensitive to anti-vector neutralizing activity, while displaying desirable characteristics, such as transduction of non-dividing cells, including antigen-presenting cells, and long-term transgene expression. |
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Keywords: | Lentivirus HIV Vaccine |
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