erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines |
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| Authors: | Knowlden Janice M Gee Julia M W Barrow Denise Robertson John F Ellis Ian O Nicholson Robert I Hutcheson Iain R |
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| Affiliation: | (1) Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK;(2) Professorial Unit of Surgery, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK;(3) Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK;(4) Department of Pharmacology, Radiology & Oncology, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK |
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| Abstract: | Introduction Recently we reported that insulin receptor substrate 1 (IRS-1), classically an adaptor protein for the insulin-like growth factor type I receptor (IGF-IR), associates with the epidermal growth factor receptor in oestrogen receptor (ER)-positive (ER+) tamoxifen-resistant breast cancer cells. In this study, we examined whether IRS-1 also associates with another erbB receptor family member, erbB3, and what impact this might have on IGF-IR signalling in three ER+ breast cancer cell lines. |
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| Keywords: | breast cancer erbB3 IRS-1 IGF-IR resistance |
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