A Noninvasive [<Superscript>99m</Superscript>Tc]DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A Noninvasive [99mTc]DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD

Authors:	Yanjun Wu Charles J. Kotzer Sokratis Makrogiannis Gregory A. Logan Hyking Haley Mary S. Barnette Susanta K. Sarkar

Affiliation:	(1) Molecular Imaging Center of Excellence, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USA;(2) Respiratory CEDD, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USA;(3) Laboratory Animal Science, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USA;(4) Medicines Development, Oncology R&D, GlaxoSmithKline, Collegeville, PA 19426, USA

Abstract:	Purpose The purposes of this study are (1) to develop an efficient aerosol inhalation system for the delivery of [^99mTc]DTPA aerosol into guinea pig airways with high uniformity for measuring lung clearance using SPECT/CT imaging, as a measure of lung permeability, and (2) to use [^99mTc]DTPA studies in guinea pig model of chronic obstructive pulmonary disease (COPD) to determine its usefulness in studying pathogenesis of COPD.

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