温度敏感瞬时受体电位通道参与化疗引起的外周神经病变的研究进展

化疗所引起的外周神经病变（CIPN）是临床抗肿瘤治疗过程中常见的剂量限制性毒性。外周神经系统中所分布的温度敏感瞬时受体电位通道（thermoTRPs）在CIPN的发生发展中发挥了关键的作用,参与了CIPN神经性痛觉过敏等症状形成。化疗药物可通过多种途径激活thermoTRPs或导致其异常表达。研究thermoTRPs在CIPN中的作用及其机制具有重要意义。本文综述了近年来有关于thermoTRPs参与CIPN的相关研究以及临床治疗进展。

New Progress of the Study on the Roles of ThermoTRPs in Chemotherapy-induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy（CIPN） is a common significant side effect resulting from the administration of several chemotherapeutic agents.In recent years,related studies found temperature-sensitive transient receptor potential channels（so-called thermoTRPs） play certain roles in the development of CIPN.Especially,these TRP channels are key players in hyperpathia.Several evidences from in vitro and in vivo studies in animals or humans have proved thermoTRPs to be potential targets for the treatment or prevention of CIPN.Developing TRP channel antagonists as a new generation of CIPN therapeutics may become beneficial.