急性冠状动脉综合症患者抗血小板治疗策略研究进展

血小板的激活在急性冠脉综合症的发生中起着重要的作用,阿司匹林联合二磷酸腺苷受体拮抗剂是目前抗血小板治疗的金标准,但临床发现不同患者对抗血小板药物的反应性存在显著的个体差异。本文主要从氯吡格雷的体内药动药效学过程出发分析其产生个体差异的影响因素,同时对目前的抗血小板治疗策略进行综述,以为临床制定安全有效的抗血小板方案提供参考。

Research Progress of Antiplatelet Treatment Strategy for Patients with Acute Coronary Syndrome

ABSTRA CT Platelet activation plays an important role in the occurrence of acute coronary syndrome.Although treatment of aspirin plus adenosine diphosphate receptor antagonists is the gold standard of antiplatelet therapy,there are significant individual differences with different patients respond to antiplatelet drugs.This article mainly analyzed the influence factors of individual differences from the process of clopidogrel’s pharmacokinetics and pharmacodynamics,and reviewed the research progress of antiplatelet treatment strategy,as to provide reference for clinic to formulate a safe and effective therapeutic regimen of antiplatelet treatment.