NEUT-X、NEUT-Y参数在细菌感染诊断中的价值探讨

目的探讨Sysmex XT-2000i全自动血液分析仪中性粒细胞NEUT-X和NEUT-Y参数对细菌感染诊断的临床意义。方法用Sysmex XT-2000i全自动血液分析仪检测114例细菌感染患者、96例细菌培养阴性组与142名健康体检者(正常对照组)血液样本,分析比较各组中性粒细胞参数NEUT-X、NEUT-Y、C反应蛋白(CRP)和毒性指数(TI)等结果。结果感染组中性粒细胞NEUT-X、NEUT-Y参数分别为1 391.4±42.3、450.9±40.9,细菌培养阴性组分别为1 344.5±37.0、422.7±45.9,正常对照组分别为1 351.7±33.7、415.8±32.2,各组间差异均有统计学意义(P0.01)。NEUT-X、NEUT-Y参数与CRP和TI均具有较好的相关性。用于细菌感染诊断时,CRP诊断效能最高,其次为NEUT-X。当CRP、NEUT-X的临界值(Cut-off值)分别取20.5 mg/L、1 370.5时,敏感性分别为94.7%、71.1%,特异性分别为71.4%、75.6%。结论感染性疾病患者NEUT-X和NEUT-Y参数明显升高,可作为感染性疾病诊断辅助指标之一。

Investigation on the significance of NEUT-X and NEUT-Y parameters for the diagnosis of bacterial infection

Objective To investigate the clinical significance of Sysmex XT-2000i automatic hematology analyzer′s neutrophil parameter NEUT-X and NEUT-Y in the diagnosis of bacterial infection.Methods Blood samples were collected from 1 14 patients with bacterial infection,96 patients with bacterial culture negative and 142 healthy subjects （healthy control group）to detect and analyze NEUT-X,NEUT-Y,C-reactive protein （CRP）and toxity indices （TI）. Results NEUT-X and NEUT-Y were 1 391.4 ±42.3 and 450.9 ±40.9 respectively in bacterial infection group,which were significantly higher than in bacterial culture negative group （1 344.5 ±37.0 and 422.7 ±45.9）and healthy control group（1 351.7 ±33.7 and 415.8 ±32.2）with statistical significance（P＆lt;0.01）.NEUT-X and NEUT-Y were correlated with CRP and TI.For the diagnosis of bacterial infection,CRP had the best diagnosis efficacy,and NEUT-X had the secondary diagnosis efficacy.When the cut-off value of CRP and NEUT-X were 20.5 and 1 370.5,the sensitivities were 94.7% and 71.4%,and the specificities were 71.4% and 75.6%,respectively.Conclusions NEUT-X and NEUT-Y parameters increase significantly after bacterial infection.It can be used as assistant diagnosis parameters of bacterial infection.