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| N-叔丁基(4aS,8aS)-十氢异喹啉-3(S)-甲酰胺的合成及结构表征 | |
| 引用本文： | 赵秀雅,李荣梅,马程军,张关永. N-叔丁基(4aS,8aS)-十氢异喹啉-3(S)-甲酰胺的合成及结构表征[J]. 医学教育探索, 2006, 0(12): 1449-1453 |
| 作者姓名： | 赵秀雅 李荣梅 马程军 张关永 |
| 作者单位： | 华东理工大学化学与分子工程学院 上海200237 |
| 摘 要： | 以L-苯丙氨酸为原料制备N-叔丁基-1,2,3,4四-氢异喹啉-3(S)甲-酰胺(T ICC),后者经铑/氧化铝催化加氢制备N-叔丁基(4aS,8aS)十-氢异喹啉-3(S)甲-酰胺(DH IQ)。1H-NMR、M S确定产物的化学结构;GC-M S分析产物中的异构体;单晶X射线衍射确定DH IQ的绝对构型;旋光度的测定表明DH IQ产物的光学纯度达到了98%。 |
| 关 键 词： | L-苯丙氨酸 N-叔丁基-1 2 3 4-四氢异喹啉-3(S)-甲酰胺 铑/氧化铝 单晶X射线衍射 N-叔丁基(4aS 8aS)-十氢异喹啉-3(S)-甲酰胺 |
| 收稿时间： | 2005-12-15 |
Synthesis and Structure Characterization of N-Tert-butyldecahydro (4aS,8aS)-isoquinoline-3(S)-carboxamide |
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| ZHAO Xiu-y,LI Rong-mei,MA Cheng-jun,ZHANG Guan-yong. Synthesis and Structure Characterization of N-Tert-butyldecahydro (4aS,8aS)-isoquinoline-3(S)-carboxamide[J]. Researches in Medical Education, 2006, 0(12): 1449-1453 | |
| Authors: | ZHAO Xiu-y LI Rong-mei MA Cheng-jun ZHANG Guan-yong |
| Abstract: | With L-phenylalanine,N-tert-butyl-1,2,3,4-tetrahydro-3(S)-isoquindinecarbox amide(TICC) was prepared firstly,then it was hydrogenated over rhodium-on-Al_2O_3,N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide(DHIQ) was synthesized and identified by()~1H-NMR spectra,MS spectra.Then isomers in the resulting compound and its absolute configuration were analyzed by GC-MS and X-ray diffraction.Finally optical rotation shows its optical purity reaches 98%. |
| Keywords: | L-phenylalanine N-tert-butyl-1 2 3 4-tetrahydro-3(S)-isoquindinecarbox amide rhodium-on-Al_2O_3 X-ray diffraction N-tert-butyldecahydro(4aS 8aS)-isoquinoline-3(S)-carboxamide |
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