246例非小细胞肺癌的预后影响因素分析

目的:分析246例非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的预后影响因素.方法:回顾性分析2010年1月至2014年12月246例非小细胞肺癌患者临床资料,采用Kaplan-Meier法进行生存分析,Log-rank检验和Cox模型预后影响因素行单因素和多因素分析.结果:全组患者中位生存时间为37.44个月.1年、3年、5年总生存率分别为72％、46％、26％.单因素分析显示,男性、年龄＞75岁、晚期、有吸烟史、有肝转移、无手术史非小细胞肺癌患者的中位生存期明显缩短(P＜0.05或P＜0.01).多因素分析显示,性别、疾病分期、是否吸烟和是否手术是影响非小细胞肺癌预后的独立因素(P ＜0.05或P＜0.01).结论:性别、疾病分期、是否吸烟和是否手术是非小细胞肺癌的独立预后因素.

Analysis of prognostic factors in 246 patients with non-small cell lung cancer

Objective:To analyze prognostic factors in non-small cell lung cancer(NSCLC).Methods:The data of 246 patients with NSCLC from January 2010 to December 2014 were analyzed in this study.Kaplan-Meier method was used for survival analysis,and Log-rank test and Cox regression were used for univariate and multivariate analyses of prognostic factors.Results:The median survival time of all patients was 37.44 months.The 1-,3-,and 5-year overall survival rates were 72％,46％ and 26％,respectively.The univariate analysis showed male,age ＞ 75 years old,advanced,smoking,liver metastases,no surgery reduced the overall survival time in patients with NSCLC.The multivariate analysis showed that gender,disease stage,pathological types,taking surgery were independent factors affecting the prognosis for NSCLC patients.Conclusion:Gender,disease stage,smoking history,surgery history were independent factors for the overall survival of NSCLC.