切除修复交叉互补基因1与卵巢癌发病的相关性

目的:探索ERCC1与卵巢癌发病的相关性.方法:收集2013年至2016来我院就诊的卵巢癌患者30例作为病例组,以同一时期来我体检中心常规体检的患者61例作为对照组,进行病例-对照研究.分析研究对象ERCC的单核细胞多态性.结果:ERCC1-8092TT基因型携带者的卵巢癌发生概率高于8092CC基因型,但未见统计学差异.结论:中国北方人群ERCC1基因多态性与卵巢癌发病无相关性.未来需要开展基于人群的大样本随机抽样研究以验证这一结论.

Correlation of ERCC1 genes and ovarian cancer risk-A case control study

Objective:To explore the correlation of ERCC1 and ovarian cancer risk.Methods:30 patients diagnosed as ovarian cancer by the research hospital between 2013 and 2016 were recruited as case group,and 61 healthy participants were also recruited in the same period at the physical health examination department of the hospital.Results:ERCC1-8092TT carriers showed a higher risk of ovarian cancer compared to 8092CC carriers.However,the differences are not statistically significant.Conclusion:No relation is present between ERCC1 SNPs and ovarian cancer risks for northeast Chinese population.Larger sample studies with randomization design should be held to obtain conclusive evidence.