晚期原发性肝癌治疗的研究进展

原发性肝癌位居全球最常见恶性肿瘤的第五位,在癌症相关死亡原因中排名第三位.原发性肝癌治疗方法的选择很大程度上取决于肝脏功能,肿瘤大小,是否存在转移灶和血管侵犯.目前,原发性肝癌的根治方法包括肝切除术和肝移植手术,但是很多患者确诊时已进入晚期,失去了治愈的机会.全身系统性治疗对于晚期原发性肝癌的患者变得尤为重要,其中包括:分子靶向治疗、全身系统性化疗和免疫治疗.本文就近年来晚期原发性肝癌治疗的研究进展作一综述.

Progress of therapies for the advanced hepatocellular carcinoma

The incidence of primary liver cancer continues to increase rapidly in recent years.Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer and is the third leading cause of cancer death worldwide.The treatment of HCC is determined by the liver function,tumor size,metastasic pattern and the vascular invasion.Surgical resection and liver transplantation remain the only possibility for cure in HCC.Most patients lose the chance of topical treatment since they are already in advanced stage when they diagnosed.Systemic therapy is particularly important for patients with advanced HCC,including targeted agent,chemotherapy and immunotherapy.In this review,we discuss the current situation and progress of systemic therapies for the advanced HCC.