Annexin A2与肿瘤侵袭和转移关系的研究进展

肿瘤的发生、发展是一个多步骤的复杂过程,涉及细胞内多分子异常、肿瘤细胞及肿瘤微环境的相互作用等多方面因素.尽管外科手术、放射治疗和化学治疗已取得了巨大的进步,但是在阻断肿瘤进程上并未有实质性突破.肿瘤的侵袭和转移是决定肿瘤患者死亡的关键因素.目前研究表明,Annexin A2广泛参与肿瘤细胞的黏附、增殖、侵袭、转移和新生血管的生成.因此临床上研究Annexin A2与肿瘤侵袭和转移的关系能为肿瘤的治疗提供依据和参考.本文就Annexin A2的特性、Annexin A2在肿瘤细胞中的表达,尤其对Annexin A2与各类型肿瘤侵袭和转移的关系展开综述.

Progress of Annexin A2 and tumor invasion and metastasis

The occurrence and development of tumor is a multi-step complex process,involving many factors,such as multi-molecular abnormalities,interaction of tumor cells and tumor microenvironment.Despite of surgery,radiation therapy and chemotherapy have made great progress.However,the process of blocking the tumor did not have a substantive breakthrough.Tumor invasion and metastasis ate the key factors to determine the death of cancer patients.Current studies show that Annexin A2 is widely involved in the adhesion,proliferation,invasion,metastasis and angiogenesis of tumor cells.The clinical study of the relationship between invasion,metastasis and Annexin A2 can provide a basis and reference for the tumor treatment.In this article,the characteristics of Annexin A2,the expression of Annexin A2 in tumor cells,and the relationship between the invasion,metastasis and Annexin A2 in various types of tumors are reviewed.