血清肌抑素水平与胃癌恶病质的关系

目的 观察胃癌恶病质患者血清肌抑素水平变化,并初步探讨肌抑素与肿瘤坏死因子-α的相关性.方法 根据整体营养状况主观评估(PG-SGA)分级将80例胃癌患者分成胃癌恶病质组(PG-SGAC级,32例)和胃癌非恶病质组(PG-SGA A+B级,48例),采用ELISA法测定血清肌抑素和肿瘤坏死因子-α水平,并记录身高、体质量、总蛋白、白蛋白、血红蛋白、C-反应蛋白等指标.对照组为健康体检者80例,同法测定并记录上述指标.结果 胃癌恶病质组的血清肌抑素水平为(1.36±0.50) μg/L,显著高于胃癌非恶病质组的(0.91 ±0.49) μg/L(x2=14.67,P=0.00)；对照组的血清肌抑素水平为(0.70±0.37) μg/L,显著低于胃癌非恶病质组(x2=36.45,P=0.00).对照组(r=-0.16,P=0.16)、胃癌非恶病质组(r=0.08,P=0.58)及胃癌恶病质组(r=0.18,P=0.31)中血清肌抑素与肿瘤坏死因子-α浓度均不具有相关性.结论 胃癌恶病质患者血清肌抑素水平升高；血清肌抑素与肿瘤坏死因子-α无相关性.

Relationship between serum myostatin and gastric carcinoma-associated cachexia

Objective To observe the changes of serum myostatin （MSTN） level in patients with gastric carcinoma-associated cachexia and to investigate the relationship between MSTN and tumor necrosis factor α （TNF-α） preliminarily. Methods Eighty patients with gastric cancer were divided into two groups based on their Patient-Generated Subjective Global Assessement （PG-SGA） scores： gastric carcinoma-associated cachexia group （GCC group, 32 cases; PG-SGA stage C） and gastric carcinoma non-cachexia group （GCNC, 48 cases; PG-SGA stage A＋ B）. The serum MSTN and TNF-α levels were measured by enzyme linked immunosorbent assay, and rele- vant parameters including height, weight, albumin, hemoglobin, and C-reactive protein were also recorded before operation. Eighty healthy adults were chosen as the control group. Results The serum MSTN level in the GCC group [ （ 1.36 ±0. 50） μg/L] was significantly higher than that in the GCNC group [ （0.91 ±0.49） μg/L; χ2 = 14. 67, P = 0. 00 ], whereas the serum MSTN level in the GCNC group was significantly higher than that in the con- tml group [ （0. 70 ± 0. 37 ） μg/L;χ2= = 36. 45, P =0. 00 ]. Serum MSTN level was not correlated with TNF-α in the GCCgroup （r=0.18, P=0.31）, GCNC group （r=0.08, P=0.58）, or control group （r= -0.16, P= 0. 16）. Conclusions Serum MSTN level is elevated in patients with gastric carcinoma-associated cachexia. How- ever, it is not correlated with serum TNF-α.