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Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins
Authors:Huang Xiao-Li  Fan Zheng  Zheng Lian  Borowski Luann  Li Hongyi  Thomas Elaine K  Hildebrand William H  Zhao Xiao-Qing  Rinaldo Charles R
Affiliation:Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
Abstract:Proteins may serve as ideal CD8(+) T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway. This study shows that human blood monocyte-derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8(+) T cells to HIV-1 in vitro. Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols.
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