胆管癌与肝炎病毒感染相关性研究

目的:调查胆管癌患者血清中肝炎病毒标志物检出率,探讨胆管癌发生与肝炎病毒感染的相关性.方法:收集天津地区11年间3所医院305例胆管癌的临床资料,统计其中肝炎病毒感染率和肝炎病毒危险因素接触状况,调查住院期间血清肝炎病毒标志物检出情况.调查了同期住院的480例良性胆道疾病患者作为对照.结果:胆管癌和良性胆道疾病患者既往乙型肝炎病毒(HBV)感染率分别为3%和2.5%;29%的胆管癌病例可以检出HBV的血清标志物,而良性胆道疾病病例HBV血清标志物的检出率为21%,二者有显著差异.丙型肝炎病毒(HBV)的血清标志物检出率在胆管癌为4.3%,在良性胆道疾病为5.6%,二者比较无差别.结论:胆管癌患者中并发HBV感染率较高,HBV感染与胆管癌的发生可能存在一定的关系.由于HCV的检测指标单一,目前尚不能排除胆管癌发生与HCV感染无关.

Relationship between Bile Duct Carcinoma and Hepatitis Viral Infection

Objective To investigate the presence of serological markers in patients with bile duct carcinoma(BDC) and to study the relationship between hepatitis viral infection and carcinogenesis of the bile duct [WTHZ]Methods [WT] Clinical data of 305 cases of BDC and 480 cases of nonmalignant disease of the bile duct (NDBC) were collected in three hospitals of Tianjin district during 11 years. The infectious rate of viral hepatitis was observed and the risk factors for hepatitis virus infection in patients before their hospitalization were analyzed, and serological markers of hepatitis virus were surveyed during hospitalization. Results Three percent of BDC patients and 2.5% of NDBC patients had a history of HBV infection before hospitalization. The serological markers for HBV could be assayed in 29% of BDC patients and 21% of NDBC patients with significant differences between the two groups. The serological markers for hepatitis C virus(HCV) could only be assayed in 4.3% of BDC patients and 5.6% of NDBC patients with no diiffrence between them. Conclusion There was a high incidence of HBV infection in BDC. HBV infection might have association with the pathogenesis of BDCs. As one serological markers of HCV could be assayed, it could hardly be concluded that HCV infection had no cassociation with the carcinogenesis of BDC.