母亲高脂血症增加后代疾患动脉粥样硬化的机制

流行病学和病理研究证据表明，胚胎发育期间母体高脂血症增加了后代成年后动脉粥样硬化的风险。在子宫、胎盘和胎儿暴露于来自母亲的高胆固醇、脂质入侵、氧化应激、炎症和免疫反应等信号，胎儿对这些反应可能导致表观遗传的改变，使其在成年后动脉粥样硬化易感性增加。

Mechanism of Mathernal Hyperlipidemia Increasing Offspring Atherosclerosis

An increasing amount of epidemiological and pathological evidence has been provided that indicates that maternal hyperlipidemia during embryonic development is correlated with an increased risk for atherosclerosis in the offspring during adulthood. In utero, the placenta and fetus are exposed to high cholesterol, lipid invasion, oxidative stress, inflammation and immune reaction signals from the mother and will likely respond specifically. In the fetus, these responses may lead to permanent epigenetic changes and these changes may lead to increased atherosclerosis susceptibility in adulthood.