|
|||||
|
|
Development of High Performance LiquidChromatography and Mass Spectrometry: a Key Engineof TCM Modernization |
|
| Authors: | Zheng-Xiang Zhang Xue Qiao Min Ye Man-Yu Zhang Yue Song Tao Bo |
| Affiliation: | Agilent Technologies (China) Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing 100102,P.R.China,State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China,State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China,Agilent Technologies (China) Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing 100102, P.R. China,Agilent Technologies (China) Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing 100102, P.R. China and Agilent Technologies (China) Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing 100102, P.R. China |
| Abstract: | Traditional Chinese Medicine (TCM) has been popular for thousand years in prevention and treatment of chronic diseases synergistically withWestern medicine while producing mild healing effects and lower side effects. Although many TCMs have been proven effective by modernpharmacological studies and clinical trials, their bioactive constituents and the remedial mechanisms are still not well understood. Researchershave made great efforts to explore the real theory of TCM for many years with different strategies. Development of high performance liquidchromatography (HPLC) and mass spectrometry within recent decade can provide scientists with robust technologies for disclosing themysterious mask of TCM. In this paper, important innovations of HPLC and mass spectrometry are reviewed in the application of TCManalysis from single compound identification to metabolomic strategy. |
| Keywords: | TCM High performance liquid chromatography Mass spectrometry Metabolomics Active ingredients Quality control |
| 点击此处可从《World Journal of Traditional Chinese Medicine》浏览原始摘要信息 | |
| 点击此处可从《World Journal of Traditional Chinese Medicine》下载免费的PDF全文 | |