| 拉萨地区藏族人群17个短串联重复序列基因座的遗传多态性 |
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| 引用本文： | Ma J,Ba HJ,Zhang WJ,Li K. 拉萨地区藏族人群17个短串联重复序列基因座的遗传多态性[J]. 中国医学科学院学报, 2011, 33(4): 397-401. DOI: 10.3881/j.issn.1000-503X.2011.04.010 |
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| 作者姓名： | Ma J Ba HJ Zhang WJ Li K |
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| 作者单位： | 1. 江苏省常州市公安局刑事警察支队,江苏常州,213003
2. 南京医科大学法医学系,南京,210029 |
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| 摘 要： | 目的 调查拉萨地区藏族人群17个短串联重复序列(STR)基因座的遗传多态性分布.方法 采用国产AGCU17+1荧光标记复合扩增试剂盒,结合AB9700扩增仪和3130XL遗传分析仪,对拉萨地区132名藏族无关个体的静脉血进行基因组多态性检测,并用GeneMapper 3.2软件进行基因分型.结果 17个STR基因座在132名藏族无关个体中的等位基因频率介于0.0038～0.5720,个体识别能力介于0.779 ～0.979,非父排除率值介于0.327 ～0.737,多态信息含量介于0.538～0.910,杂合度介于0.629～0.871.累积耦合概率为3.93×10-20,累积非父排除率为0.9999995234.17个STR基因座中,Penta E与D6S1043的各项多态性指标均为最高,TPOX基因座的各项指标值均为最低.结论 17个STR基因座在藏族人群的多态性研究中具有较高的应用价值,可用于该地区的群体学研究、法医学个体识别等领域.
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| 关 键 词： | 短串联重复序列 遗传多态性 群体遗传学 藏族 |
Polymorphism of 17 short tandem repeat Loci of tibetan minority ethnic group from Lhasa |
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| Ma Jun,Ba Hua-jie,Zhang Wen-jie,Li Kai. Polymorphism of 17 short tandem repeat Loci of tibetan minority ethnic group from Lhasa[J]. Acta Academiae Medicinae Sinicae, 2011, 33(4): 397-401. DOI: 10.3881/j.issn.1000-503X.2011.04.010 |
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| Authors: | Ma Jun Ba Hua-jie Zhang Wen-jie Li Kai |
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| Affiliation: | MA Jun1,BA Hua-jie1,ZHANG Wen-jie1,LI Kai2 1Detachment Criminal of Public Security Bureau of Changzhou,Changzhou,Jiangsu 213003,China 2Department of Forensic Science,Medical College of Nanjing,Nanjing 210029,China |
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| Abstract: | Objective To investigate the polymorphism of 17 short tandem repeat(STR) loci of Tibetan minority ethnic group from Lhasa.Methods Blood samples were obtained from 132 unrelated Tibetan individuals from Lhasa.DNA templates were screened by home-made AGCU17+1 kit and 3130XL genetic analyzer.Genotyping was performed using GeneMapper software(version 3.2).Results The allele frequencies of 17 STR loci ranged 0.0038-0.5720,and the power of discrimination ranged 0.779-0.979,the power of exclusion ranged 0.327-0.73... |
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| Keywords: | short tandem repeat genetic polymorphism population genetic analysis Tibetan |
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