抗精神病药物对精神分裂症患者心电图的影响

目的探讨抗精神病药物对精神分裂症患者心电图的影响。方法对100例精神分裂症患者应用抗精神病药物治疗前后各周的心电图变化进行监测,并进行统计分。结果入组的100例精神分裂症患者服用抗精神病药物治疗后心电图均有不同程度的改变,服用氯丙嗪、氯氮平、氟哌啶醇、奋乃静治疗的患者心电图异常改变发生率较高,以窦性心动过速、T波改变、ST段下移为多见,其次为窦性心动过缓,室性早搏和QT间期延长;传导阻滞较少见,少部分患者出现QTc间期延长。结论抗精神病药物对精神分裂症患者心电图有一定影响,在应用抗精神病药物治疗时应定期监测心电图的变化,为及时有效的防治提供依据。

Effects of antipsychotics on ECG of schizophrenics

Objective To explore the effects of antipsychotics on ECG of schizophrenics. Methods ECG changes before treatment and during each week after treatment were monitered and statistically analyzed in 100 schizophrenics on antipsychotics. Results After treatment, ECGs of all patients had changes in different degree, incidences of ECG abnormal changes of the patients on chlorpromazine, clozapine, haloperidol and perphenazine were higher, those were mainly sinus tachycardia and T wave changes, then sinus bradycardia, ventricular premature beat and QT interval prolongation; conduction block was rare, few patients showed up QTc interval prolongation. Conclusion Antipsychotics have a certain effect on ECG of schizophrenics, ECG changes should be monitered regularly when patients take antipsychotics to provide basis for promptly effective prevention and cure.