| 1-取代苄氧基-3,6,7-三羟基-氧杂蒽酮的合成及NCI-H460细胞抑制活性研究 |
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| 引用本文： | 张晔,吴玮峰,陆赛花,刘秀凤,徐峰.1-取代苄氧基-3,6,7-三羟基-氧杂蒽酮的合成及NCI-H460细胞抑制活性研究[J].西北药学杂志,2016(1):83-85. |
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| 作者姓名： | 张晔 吴玮峰 陆赛花 刘秀凤 徐峰 |
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| 作者单位： | 上海市奉贤区中心医院药剂科,上海,201499 |
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| 摘 要： | 目的研究苄基上不同的取代基对1-取代苄氧基-3,6,7-三羟基-氧杂蒽酮类化合物细胞毒性的影响。方法设计合成氧杂蒽酮类化合物8个,所有化合物均经过核磁确证,并进行了初步的细胞毒活性筛选。结果和结论所合成8个化合物属首次报道,其中6个化合物对NCI-H460肿瘤细胞产生抑制作用,目标产物1b、1d、1e和1f作用较强。
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| 关 键 词： | 氧杂蒽酮 细胞毒性 合成 |
Synthesis of 1-substituted benzyl-oxy-3,6,7-trihydroxyl xanthone with NCI-H460 cells inhibitory activity evaluation |
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| Abstract: | Objective To study the influence on cytotoxicity of 1-substituted benzyl-oxy-3 ,6 ,7-trihydroxyl xanthone with different benzyl groups .Methods Eight target compounds were designed and synthesized .Their structures were confirmed by 1 H-NMR spectra .Results and Conclusion All of the target compounds were reported for the first time .The results of preliminary phar-macological test showed that all the target compounds exhibited potent NCI-H460 cell inhibitory activity ,of which the compound 1b ,1d ,1e and 1f showed the highest activity . |
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| Keywords: | xanthone cytotoxicity synthesis |
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