| 氟的遗传毒性研究 |
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| 引用本文： | 马凤,吴云鹏,梁超轲,Y.Li,G.K.Stookey,B.P.Katz,E.J.Brizendine.氟的遗传毒性研究[J].医学研究杂志,2000(3). |
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| 作者姓名： | 马凤 吴云鹏 梁超轲 Y.Li G.K.Stookey B.P.Katz E.J.Brizendine |
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| 作者单位： | 中国预防医学科学院环境卫生与卫生工程研究所，中国预防医学科学院环境卫生与卫生工程研究所，中国预防医学科学院环境卫生与卫生工程研究所，美国印第安纳大学，美国印第安纳大学，美国印第安纳大学，美国印第安纳大学 北京 100050，北京 100050，北京 100050，IN 46202，IN 46202，IN 46202，IN 46202 |
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| 基金项目： | 美国 NIH/NID PHS/POI DE-09835研究基金 |
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| 摘 要： | 本文报道燃煤污染高氟与饮水高氟暴露人群外周血淋巴细胞姊妹染色单体交换(SCE)频率。不同燃煤氟暴露人群4个组和不同饮水氟暴露人群6个组,年龄4O～60岁,每组120人。该结果经统计学分析,高、低氟接触不同人群组之间SCE频率没有差异,即未发现氟的遗传毒性。
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| 关 键 词： | 燃煤型氟中毒 饮水型氟中毒 氟化物 遗传毒性 人淋巴细胞 姐妹染色单体交换 |
Study on the geuotoridty of fluoride |
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| Y. Li,G. K. Stookey,B. P. Katz and E. J. Brizendine Ma Feng,Wu Yunpeng,Liang Chaoke.Study on the geuotoridty of fluoride[J].Journal of Medical Research,2000(3). |
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| Authors: | Y Li G K Stookey B P Katz and E J Brizendine Ma Feng Wu Yunpeng Liang Chaoke |
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| Institution: | Y. Li,G. K. Stookey,B. P. Katz and E. J. Brizendine Ma Feng,Wu Yunpeng,Liang Chaoke,Institute of Environmental Health and Engineering,Chinese Academy of Preventive Medicine,Beijing 100050. |
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| Abstract: | The investigation was to determine on the genotoxicity of fluoride by fanner's long - term exposure in coal burning fluorosis as well as drinking water fluorosis epidemic areas. The sister chromatid exchange (SCE) frequency in blood lymphocytes from these subjects who were 40 ~ 60 years old. 4 coal burning group and 6 drinking water groups, each groupl20individuals were analyzed. The results demonstrated that different fluoride level exposure in indoor air and drinking water does not increase SCE frequency, and conclude that fluoride have no genotoxic effects in humans. |
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| Keywords: | Coal burning fluorosis Drinking water fluorosis Fluoride Genotoxicity Lymphocytes Sister chromaticy exchange |
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