骨髓基质细胞治疗脑梗死的研究现状

目前,治疗脑梗死的药物虽然很多,但均未取得满意疗效.骨髓基质细胞(mesenchymalstromal cell,MSC)具有多向分化潜能和自我更新能力,可分化为神经细胞.通过分泌营养因子和生长因子、促进血管发生等机制,移植的MSC能改善梗死后神经功能缺损,促进神经功能恢复,从而降低脑梗死的致残率.利用MSC进行细胞移植很可能成为治疗脑梗死的一种理想手段.

Mesenchymal stromal cells for cerebral infarction

Although there are many drugs for the treatment'of cerebral infarction, no satisfactory efficacy has achieved. Mesenehymal stromal cells (MSCs) have multilineage differentiation potential and self-renewing capability, and can differentiate into neurons. The transplanted MSCs can improve neurological deficit after cerebral infarction, promote the recovery of neurological function, and thereby reduce the disability of cerebral infarction through the mechanisms such as releasing nutritional factors and growth nutritional factors, promoting angiogenesis. The use of MSCs for cell transplantation is likely to be an ideal means in the treatment of cerebral infarction.