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Glucocorticoids Decrease Hippocampal and Prefrontal Activation during Declarative Memory Retrieval in Young Men |
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| Authors: | Nicole Y. L. Oei Bernet M. Elzinga Oliver T. Wolf Michiel B. de Ruiter Jessica S. Damoiseaux Joost P. A. Kuijer Dick J. Veltman Philip Scheltens Serge A. R. B. Rombouts |
| Affiliation: | (1) Leiden University Institute for Psychological Research, Leiden University, Wassenaarseweg 52, PO Box 9555, 2300 RB Leiden, The Netherlands;(2) Leiden Institute for Brain and Cognition, Leiden, The Netherlands;(3) Department of Psychology, University of Bielefeld, Bielefeld, Germany;(4) Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;(5) Alzheimer Center, Free University Medical Center, Amsterdam, The Netherlands;(6) Department of Neurology, Free University Medical Center, Amsterdam, The Netherlands;(7) Department of Physics & Medical Technology, Free University Medical Center, Amsterdam, The Netherlands;(8) PET Center, Free University Medical Center, Amsterdam, The Netherlands;(9) Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands |
| Abstract: | Glucocorticoids (GCs, cortisol in human) are associated with impairments in declarative memory retrieval. Brain regions hypothesized to mediate these effects are the hippocampus and prefrontal cortex (PFC). Our aim was to use fMRI in localizing the effects of GCs during declarative memory retrieval. Therefore, we tested memory retrieval in 21 young healthy males in a randomized placebo-controlled crossover design. Participants encoded word lists containing neutral and emotional words 1 h prior to ingestion of 20 mg hydrocortisone. Memory retrieval was tested using an old/new recognition paradigm in a rapid event-related design. It was found that hydrocortisone decreased brain activity in both the hippocampus and PFC during successful retrieval of neutral words. These observations are consistent with previous animal and human studies suggesting that glucocorticoids modulate both hippocampal and prefrontal brain regions that are crucially involved in memory processing. Electronic Supplementary Material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
| Keywords: | fMRI Glucocorticoids Hippocampus Memory retrieval PFC |
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