| 用单克隆抗体观察慢性肝炎患者细胞免疫状况的变化 |
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| 引用本文： | 封江南 姚启湘. 用单克隆抗体观察慢性肝炎患者细胞免疫状况的变化[J]. 免疫学杂志, 1989, 5(2): 47-50 |
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| 作者姓名： | 封江南 姚启湘 |
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| 作者单位： | 卫生部武汉生物制品研究所免疫研究室，卫生部武汉生物制品研究所免疫研究室，卫生部武汉生物制品研究所免疫研究室，空军汉口医院，空军汉口医院，空军汉口医院，空军汉口医院 武汉，武汉，武汉 |
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| 摘 要： | 本文用多种单克隆抗体对32例慢性肝炎患者的细胞免疫状况进行了研究。结果发现患者肝组织内淋巴细胞和单核、巨噬细胞浸润明显增加,坏死区浸润细胞主要是T_3~+和T_8~+细胞。B淋巴细胞浸润极少,浸润淋巴细胞表面IL—2受体阳性细胞与外周血淋巴细胞表面IL—2受体阳性细胞率均无改变。患者外周血单个核细胞改变为T_3~+下降,T_4/T_8比例下降,单核、巨噬细胞、B淋巴细胞及淋巴细胞表面HLA—DR、DP、DQ标志与正常人无差异。
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| 关 键 词： | 肝炎 单克隆抗体 细胞免疫 |
Studies on Cellular Immunity of Chronic Hepatitis patients with Monoclonal Antibodies |
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| Feng Jiangnan. Studies on Cellular Immunity of Chronic Hepatitis patients with Monoclonal Antibodies[J]. Immunological Journal, 1989, 5(2): 47-50 |
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| Authors: | Feng Jiangnan |
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| Affiliation: | Feng JiangnanDepartment of Immunology,Wuhan Institute for Biological Products,the Ministry of Public Health of China,Wuhan |
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| Abstract: | Cellular immunity of 32 cases of chronic hepatitis B was investigated with monoclonal anti-lyphocyte antibodies. The results showed that the infiltration of lymphocytes and monocytes and macrophages in liver tissue from chronic hepatitis B patients increased apparently and that of piecemeal necrosis region was related mainly to T3, T8 positive cells, however there was only a few B+ lyphocytes in the region. There was do difference of percentages of infiltrating lymphocytes with IL-2 receptor between patients and normal control. The results for the determination of PBL from the patients showed that the percentage of T3+ cells decreased and so did the value of T4/T8.No changes of mo-nonnuclear, macrophages, B lymphocytes with HLA-DR, DP, DQ marker between the patients and normal control occured. |
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| Keywords: | Chronic Hepatitis Monoclonal Antibodies |
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