Protection of gastric mucosa in rats |
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| Authors: | D. Foschi F. Ferrante L. Varin P. Del Soldato V. Rovati |
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| Affiliation: | (1) Department of Surgery, Institute of Biomedical Sciences, L. Sacco Hospital, University of Milan, Via G.B. Grassi, 74, 20157 Milano, Italy;(2) Present address: Formenti Pharmaceuticals, Via Di Vittorio 2, Origgio, VA, Italy |
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| Abstract: | ![]()
We have studied the protective effects of truncal vagotomy, atropine, and PGE2 against gastric mucosal injury produced by necrotizing agents (0.2 N NaOH, 0.6 N HCl, absolute ethanol), acetylsalicylic acid (ASA) and HCl, or serotonin (5HT). Vagotomy, atropine, and PGE2 prevent the effects of different noxious agents. Vagotomy is protective only against 5HT and against ASA+0.15 N or 0.35 N HCl, whereas atropine and PGE2 are also protective against the necrotizing agents. The effectiveness of vagotomy against ASA+0.35 N HCl does not depend on the inhibition of acid secretion and supports the hypothesis that removal of the vagal drive counteracts the effect of H+ back-diffusion. |
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