肥胖中青年男性颈动脉内中膜厚度相关危险因素分析

[目的]探讨肥胖中青年男性人群颈动脉内中膜厚度（CIM T ）的相关危险因素。[方法]选取81例20～50岁男性为研究对象。根据体质量指数（BM I）分为肥胖组28例（BM I ＞28 kg/m2）、超重组25例（BM I＝25～28 kg/m2）和对照组28例（ BM I＜25 kg/m2）三组。检测三组的血糖、血脂、尿酸（U A ）、睾酮（T ）、胰岛素抵抗指数及人体基本参数。[结果]中青年男性肥胖组BMI、收缩压（SBP）、甘油三脂（TG）、总胆固醇（TC）、UA、胰岛素抵抗指数（HOMA-IR）均高于超重组及对照组（ P ＜0．05），与CIMT正相关，高密度脂蛋白胆固醇（HDL-C）、T低于超重组及对照组（ P ＜0．05），与IMT呈负相关。多元线性回归显示BMI、TG是颈动脉内中膜异常的相关独立危险因素。[结论]肥胖组中青年男性存在CIMT增厚。BMI及TG是CIMT独立危险因素。

Analysis of the Related Risk Factors of Carotid Intima-media Thickness in Middle-age and Young Men with Obesity

[Objective]To explore the related risk factors of carotid intima-media thickness（CIMT） in middle-age and young men with obesity .[Methods]Totally 81 men aged 20-50 years were enrolled in the study .Accord-ing to body mass index（BMI） ,all subjects were divided into obese group（ n =28 ,BMI＆gt;28 kg/m2 ） ,overweight group（ n=25 ,BMI=25-28 kg/m2 ） and control group（ n=28 ,BMI＆lt;25 kg/m2 ） .Blood sugar ,lipids ,uric acid （UA） ,testosterone（T） ,insulin resistance index （HOMA-IR） and anthropometric parameters of 3 groups were measured .[Results]BMI ,SBP ,TG ,TC ,UA and HOMA-IR in middle-age and young obesity group were higher than those in overweight group and control group（ P ＆lt;0 .05） ,and positively correlated with CIMT .HDL-C and T in middle-age and young obesity group were lower than those in overweight group and control group （ P ＆lt;0 .05） ,and negatively correlated with IMT .Multivariant linear regression analysis showed that BMI and TG were the relative independent risk factors of abnormal carotid intima-media .[Conclusion]CIM T in middle-age and young men with obesity is increased .BMI and TG are the independent risk factors of CIMT .