代谢综合征与大肠癌相关性研究

目的探讨代谢综合征与大肠癌的相关性。方法采用病例对照的方法分析同时期住院的大肠癌患者及非肿瘤患者与代谢综合征的相关因素及差异。对比分析两组患者的体质指数（BMI）、空腹血糖（FBG）、血脂、糖尿病患病率、高血压患病率等方面的差异。结果大肠癌组代谢综合征的患病率明显高于对照组（P=0.000,OR=1.915）。随着代谢综合组分在个体聚集越多,患大肠癌的可能性越大。多因素Logisitc回归分析显示,高血压、血脂、空腹血糖对大肠癌没有显著影响,糖尿病、BMI为大肠癌发病的独立危险因素（OR=1.127,P〈0.05;OR=2.738,P〈0.05）。结论代谢综合征与大肠癌发生密切相关。BMI、糖尿病是大肠癌患病的独立危险因素,积极控制代谢综合征各危险因素对预防大肠癌患病和改善预后有重要作用。

Study on the relationship between metabolic syndrome and colorectal cancer

Objective To explore the relationship between metabolic syndrome and colorectal cancer. Methods A lipid, diabetes mellitus history, hypertension history and so on. Results The morbility rate of metabolic syndrome in colorectal cancer group was significantly higher than that in control group （P =0. 000, OR = 1. 915 ）. The incident of colorectal cancer increased significantly with the increased number of metabolic syndrome components. Logistic analysis showed that hypertension history, blood lipid and fasting blood-glucose had no marked relationship with colorectal cancer, but diabetes mellitus and BMI were correlated with the occurrence of colorectal cancer （ OR = 1. 127, P 〈0.05 ; OR = 2. 738, P 〈 0. 05）. Conclusion Metabolic syndrome is associated with colorectal cancer. BMI and diabetes mellitus are independent risk factors for colorectal cancer. Controling the individual components of metabolic syndrome can improve the prognosis of patients.