|
|||||
|
|
| 产前补充牛磺酸对室内生长受限IUGR胎鼠脑超微结构的影响 | |
| 引用本文： | 刘敬,刘丽,刘娜,陈慧. 产前补充牛磺酸对室内生长受限IUGR胎鼠脑超微结构的影响[J]. 中国儿童保健杂志, 2010, 18(5) |
| 作者姓名： | 刘敬 刘丽 刘娜 陈慧 |
| 作者单位： | 1. 北京军区总医院附属八一儿童医院新生儿监护中心,北京,100700 2. 首都医科大学基医学院解剖与组织胚胎学系,北京,100069 3. 首都医科大学附属北京妇产医院,北京,100026 |
| 基金项目： | 首都医科大学基础-临床合作基金资助项目 |
| 摘 要： | 【目的】了解宫内生长受限(intrauterine growth restriction,IUGR)胎鼠脑超微结构变化及产前补充牛磺酸对其变化的影响。【方法】将15只健康孕鼠随机分为3组:正常对照组、I UGR模型组及I UGR模型牛磺酸用药组。后两组自妊娠第1天开始饲以对照组食量的40%建立I UGR模型,牛磺酸组在饲料中添加牛磺酸300mg/(kg.d)直至自然分娩。记录胎鼠出生体重和脑重,JEM-1220透射电镜观察各组胎鼠脑超微结构变化。【结果】1)I UGR组胎鼠体重和脑重均显著低于正常对照组(P0.01);2)补充牛磺酸胎鼠出生体重和脑重均明显增加(P0.01);3)透射电镜显示I UGR胎鼠大脑和小脑皮质结构稀疏紊乱,可见大量散在分布的凋亡细胞,神经元突触数量减少,胶质细胞增生,神经元数量减少,排列稀疏。【结论】补充牛磺酸可显著改善I UGR引起的脑超微结构病理改变(透射电镜显示),从而显著改善I UGR胎鼠脑发育。 |
| 关 键 词： | 宫内生长受限 胚胎 小鼠 超微结构 牛磺酸 |
Influence of antenatal supplement of taurine on cerebral and cerebel and cerebellar ultrastracture of fetal rats with intrauterine growth |
|
| LIU Jing,LIU Li,LIU Na,CHEN Hui. Influence of antenatal supplement of taurine on cerebral and cerebel and cerebellar ultrastracture of fetal rats with intrauterine growth[J]. Chinese Journal of Child Health Care, 2010, 18(5) | |
| Authors: | LIU Jing LIU Li LIU Na CHEN Hui |
| Affiliation: | LIU Jing1,LIU Li2,LIU Na2,CHEN Hui3.(1 Department of Neonatology,Bayi Children's Hospital Affiliated with Beijing Military Region General Hospital,Beijing 100700,China,2 Department of Anatomy and Histology,Capital Medical University,Beijing 100069,3 Beijing Obstetrics and Gynecology Hospital,Beijing 100026,China) |
| Abstract: | [Objective] To explore the influence of antenatal supplement of taurine on cerebral and cerebellar ultrastructure of fetal rats with intrauterine growth restriction(IUGR).[Methods] Fifteen healthy pregnant rats were divided into control,IUGR model and taurine groups.Control group was supplied with unlimited food and drink while the other two groups were fed by 40% of food intake of control group throughout pregnancy.In taurine groups the taurines were added into diet of a dose of 300 mg/kg every day until d... |
| Keywords: | intrauterine growth restriction embryo small mouse ultrastructure taurine |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |