肝病患者血液流变学的研究

目的　探讨多种肝病患者血液流变学的改变及其不同时期内机体微循环的变化。方法　检测 82例慢性肝病患者血液流变学指标、肝功能、乙型肝炎 (乙肝 )病毒 (HBV)DNA、输血传播病毒(TTV)DNA ,并做出相关分析。结果　乙型肝炎组与正常对照组比较 :全血低切粘度、红细胞聚集指数均有明显升高 (P <0 0 5 ) ,乙肝HBVDNA与血液流变学指标间差异无显著意义 (P >0 0 5 ) ;肝硬化组与正常对照组比较 :失代偿期组红细胞压积、全血高切粘度、全血低切粘度明显降低 (P <0 0 5 ) ;代偿期组全血低切粘度、血浆粘度、红细胞聚集指数明显升高 (P <0 0 5 ) ;TTV阳性组与正常对照组 :全血高切粘度、全血低切粘度明显升高 (P <0 0 5 )。结论　乙肝患者体内有微循环障碍 ,肝硬化患者代偿期机体内呈高凝状态 ,失代偿期呈低凝状态。TTV阳性患者体内有微循环障碍 ,TTV对机体有一定的致病作用。血液流变学应作为肝病患者检查的指标。血液流变学与HBVDNA是肝病检查中相对独立的指标。

Hemorheologic changes in patients with liver diseases

Objective To study the variation of the hemorheology and microcirculation in different period of liver diseases Methods Indices for hemorheology, liver function, HBV DNA and transfusion transmitted virus (TTV) DNA were measured in 82 patients with liver diseases and correlative analysis was made Results The low shear whole blood viscosity(BV)and RBC aggregation index were significantly higher in hepatitis B group than those in the control group ( P <0 05) No correlation was found between HBV DNA and indices of hemorheology( P >0 05) The high shear and low shear BV and hematocrit (HCT)were significantly lower in decompensated cirrhosis group than those in the control group( P <0 05) RBC aggregation index, plasma viscosity(PV) and the low shear BV were significantly higher in compensated cirrhosis group than those in the control group( P <0 05) The high shear and low shear BV were significantly higher in TTV positive group than those in the control group Conclusion There is disturbance of microcirculation in the body of patients with hepatitis B or TTV infection The blood of patients with compensated cirrhosis is in highly viscose status and in low viscose status in patients with decompensated cirrhosis TTV seems to be harmful to some degree to the body The hemorheology should be an index in detecting liver diseases in addition to HBV markers