急性心肌梗死合并心房颤动心脏复律后的辛伐他汀治疗

目的 探讨不同剂量辛伐他汀治疗急性心肌梗死合并阵发性心房颤动心脏复律后的近期疗效。方法 选用急性心肌梗死合并阵发性心房颤动113例，分3组：对照组38例；辛伐他汀按剂量分2组，分别为40mg组35例、20mg组40例。随访6个月，观察血脂、心房颤动和缺血性事件。结果 ①辛伐他汀两组改善血脂优于对照组（P〈0．05），40mg组优于20mg组（P〈0．05）；②辛伐他汀两组减少心房颤动复发和转为持续性发生率优于对照组（P〈0．05），40mg组优于20mg组（P〈0．05）；③辛伐他汀两组减少缺血性事件发生率优于对照组（P〈0．05）。结论 辛伐他汀治疗急性心肌梗死发生阵发性心房颤动病人，可降低血脂、减少心房颤动复发和转为持续性心房颤动的发生率、减少缺血性事件．而且较大剂量效果更明显。

Effects of simvastatin on acute myocardial infarction with atrial fibrillation after cardioversion

Objectives To investigate the effects of different dosage of simvastatin on acute myocardial infarction with paroxysmal atrial fibrillation. Methods One hundred and thirteen patients of acute myocardial infarction with paroxysmal atrial fibrillation according to different dosage of simvastatin were divided into three groups (group 40 mg,n=35; group 20 mg,n=40; group control,n=38). The effect of lipid-lowering treatment,the recurrence of atrial fibrillation,and the ischemic events were followed up for 6 months. Results 1. In the effect of lipid-lowering treatment,group 40 mg and group 20 mg were superior to group control (P<0.05 or 0.01),group 40 mg was superior to group 20 mg (P<0.05);2. In the recurrent rate of atrial fibrillation,group 40 mg and group 20 mg were less than group control (P<0.05 or 0.01),group 40 mg was less than group 20 mg (P<0.05);3. In the rate of ischemic events,group 40 mg and group 20 mg were less than group control (P<0.05 or 0.01). Conclusions Simvastatin can lower lipid,decrease the recurrent rate of atrial fibrillation and the rate of ischemic events in patients of acute myocardial infarction with paroxysmal atrial fibrillation. These benefits from simvastatin 40mg were more obvious than from simvastatin 20 mg.