On the measurement of the functional properties of the CFTR |
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| Authors: | Oscar Moran Olga Zegarra-Moran |
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| Institution: | aIstituto di Biofisica, CNR, 16149 Genova, Italy;bLaboratorio di Genetica Molecolare, Istituto G. Gaslini, 16147 Genova, Italy |
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| Abstract: | A number of methods are currently employed to assess the functional properties of CFTR channels and their response to pharmacological potentiators, correction of the defective CFTR trafficking, and vectorial introduction of new proteins. Here we review the most common methods used to assess CFTR channel function. The suitability of each technique to various experimental conditions is discussed. |
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| Keywords: | CFTR Chloride transport Ionic current Membrane potential Chloride flux |
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