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| 裂蹄木层孔菌抗肿瘤作用及其机制研究 | |
| 引用本文： | 张问,焦燕,李航,李敬轩,蔡云,李红,杨世杰.裂蹄木层孔菌抗肿瘤作用及其机制研究[J].中草药,2011,42(10):2047-2050. |
| 作者姓名： | 张问 焦燕 李航 李敬轩 蔡云 李红 杨世杰 |
| 作者单位： | 1. 吉林大学白求恩医学院药理学系,吉林长春,130021 2. 长春日惠食用菌研究所,吉林长春,130000 3. 福建省农业科学院,福建福州,350013 |
| 摘 要： | 目的研究裂蹄木层孔菌的抗肿瘤作用及其机制。方法制备S180、H22、MFC实体瘤小鼠模型和S180腹水瘤小鼠模型。将3种实体瘤模型小鼠均分为模型组,裂蹄木层孔菌低、中、高剂量(0.5、1.0、2.0 g/kg)组和环磷酰胺(CTX)阳性对照组,S180腹水瘤小鼠模型加设对照组。观察裂蹄木层孔菌对腹水瘤小鼠生存时间以及实体瘤小鼠瘤质量、胸腺和脾脏指数、血清中白细胞介素-2(IL-2)和肿瘤坏死因子-α(TNF-α)水平的影响。结果与模型组比较,裂蹄木层孔菌低、中、高剂量均能延长S180腹水瘤小鼠的生存时间(P<0.05),抑制肿瘤生长(P<0.05),提高胸腺和脾脏指数(P<0.05)及血清IL-2(P<0.05)和TNF-α水平(P<0.01)。结论裂蹄木层孔菌对小鼠肉瘤S180、肝癌H22细胞、前胃癌MFC肿瘤的生长有明显抑制作用,显示一定的抗肿瘤效应,其可能通过提高免疫器官指数及血清中IL-2、TNF-α的水平达到抗肿瘤目的。 |
| 关 键 词： | 裂蹄木层孔菌 抗肿瘤 白细胞介素-2 肿瘤坏死因子-α 腹水瘤 |
| 收稿时间： | 2011/6/23 0:00:00 |
Antitumor effect of Phellinus linteus and its mechanism |
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| ZHANG Wen,JIAO Yan,LI Hang,LI Jing-xuan,CAI Yun,LI Hong and YANG Shi-jie.Antitumor effect of Phellinus linteus and its mechanism[J].Chinese Traditional and Herbal Drugs,2011,42(10):2047-2050. | |
| Authors: | ZHANG Wen JIAO Yan LI Hang LI Jing-xuan CAI Yun LI Hong and YANG Shi-jie |
| Institution: | ZHANG Wen1,JIAO Yan1,LI Hang2,LI Jing-xuan2,CAI Yun3,LI Hong1,YANG Shi-jie1 1.Department of Pharmacology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,China 2.Ri Hui Edible Fungi Research Institute,Changchun 130000,China 3.Fujian Academy of Agricaltural Sciences,Fuzhou 350013,China |
| Abstract: | Objective To study the antitumor effect of Phellinus linteus and preliminarily discuss its mechanism.Methods MFC-bearing,H22-bearing,S180-bearing,and S180 ascites tumors mice models were established.Five groups,model group,cyclophosphamide(CTX) group,high-(2 g/kg),middle-(1 g/kg) and low-dose(0.5 g/kg) of P.linteus groups,were studied for the former three models and a normal control group was added for S180 ascites tumors mice model.Then the life span prolongation of ascites tumor mice and tumor weight,thym... |
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